TCNJ Home : School of Science : Dept. of Chemistry : Forensic Chemistry : Forensic Chem @ TCNJ : CHE-360 Syllabus
Forensic Applications of Mass Spectrometry: Syllabus
Professor John Allison, presiding
Scheduled Class Time:
Mondays and Thursdays, 8:00 - 9:20 AM - lectures in Room 122A
Laboratory: Mondays, 9:30 - 12:20 in Room C-216
Textbook: Understanding Mass Spectra: A Basic Approach
Second Edition, R. Martin Smith, Wiley Interscience 2004
This course is designed to introduce students to the concepts of mass spectrometry - instrumentation and mass spectral interpretation - with forensic applications. No prior knowledge of mass spectrometry is required, however the course will build on basic concepts from physics, physical chemistry, and organic chemistry. If you feel that your background is weak in one of these areas, the instructor can direct you to appropriate texts.
The course grade will be based on homework, hourly exams, and class participation.
Two exams will be given - a midterm exam and a final exam. Each exam will be 15% of the Final Course Grade.
Homework performance will constitute 30% of the final course grade.
“Thursdays” will constitute 20% of the Final Course Grade.
Exams 2 x 15% 30%
The “Thursdays” Grade: The associated points indicate that this part of the course is important. It will not be productive and useful unless all students attend, are on time, and actively participate and work during the period. Each student begins with 20 points. If students choose not to attend or are late, they may lose 2 points each week and can lose up to 15 of the 20 points. The remaining 5 points will be assigned by the instructor, representing willingness and participation on Thursdays.
The course will cover as many of the topics listed below as time permits, in approximately the order listed.
Fields, Forces and Motion
Sector Instruments and Quadrupoles
Ions Formed in Mass Spectrometry
Electron Impact Ionization
Isotopes and Isotope Calculators
Part II - A Transition Topic
Part III - Analysis of Large Molecules
Desorption Ionization Methods
Fast Atom Bombardment with Sector Instruments
New Mass Limits
Fragmentation of Peptides
Electrospray Ionization with Quadrupole Mass Filters
Matrix-Assisted Laser Desorption/Ionization
Time-of-Flight Mass Spectrometry
MALDI matrices and applications
Protein Analysis and the WWW